How mechanical signals are transmitted in the cardiac myocyte is poorly understood. In this study, we produced a tamoxifen-inducible mouse model in which β1 integrin could be reduced specifically in the adult cardiomyocyte, so that the function of this integrin could be assessed in the postnatal and mechanically stressed heart.Cited by: 53.
Cardiac myocytes are the most physically energetic cells in the body. They are highly specialized high-oxygen-content cells that house a large number of mitochondria . They occupy as much as 75% of the cardiac mass, but constitute only about one thi.
Cardiac myocyte hypertrophy with pleiotropic nuclei is a common feature. However, the histopathological hallmark of HCM is cardiac myocyte disarray, which is defined as malaligned, distorted, and often short and hypertrophic myocytes oriented in different directions (Figure 25-2).Disarray may comprise 20% to 30% of the myocardium as opposed to less than 5% of the myocardium in the normal heart.
Jan 02, 2015 · The intrinsic mechanisms regulating myocyte regeneration are necessary and sufficient to preserve the integrity of the adult organ. 47 Myocyte growth, however, fails to meet the demands of the old heart and, as in humans, 27 an aging myopathy develops. 34,36,45 Similarly, the partial restoration of myocytes following ischemia or increases in Cited by: 55.